Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context.

<processor> (RISC) A processor whose design is based on the rapid execution of a sequence of simple instructions rather than on the provision of a large variety of complex instructions (as in a Complex Instruction Set Computer). Features which are generally found in RISC designs are uniform instruction encoding (e.g. the op-code is always in the same bit positions in each instruction which is always one word long), which allows faster decoding; a homogenous {register set}, allowing any register to be used in any context and simplifying compiler design; and simple addressing modes with more complex modes replaced by sequences of simple arithmetic instructions. Examples of (more or less) RISC processors are the {Berkeley RISC}, HP-PA, Clipper, i960, AMD 29000, MIPS R2000 and DEC Alpha. IBM's first RISC computer was the RT/PC (IBM 801), they now produce the RISC-based {RISC System/6000} and SP/2 lines. Despite Apple Computer's bogus claims for their PowerPC-based Macintoshes, the first RISC processor used in a personal computer was the Advanced RISC Machine (ARM) used in the Acorn Archimedes. (1997-06-03)

In computer engineering, a reduced instruction set computer (RISC) is a computer designed to simplify the individual instructions given to the computer to accomplish tasks. Compared to the instructions given to a complex instruction set computer (CISC), a RISC computer might require more instructions (more code) in order to accomplish a task because the individual instructions are written in simpler code.